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2020年版WHO胰腺肿瘤组织学分类

a.    Benign epithelial tumors/precursors良性上皮性肿瘤/前驱病变

                                          i.    Serous cystic adenoma浆液性囊腺瘤

1.    Macrocystic (oligocystic) serous adenoma

巨囊性(寡囊性)浆液性腺瘤

2.    Solid serous adenoma

实性浆液性腺瘤

3.    Von Hippel Lindau syndrome associated serious cystic neoplasm

Von Hippel Lindau综合征相关的浆液性囊腺瘤

4.    Mixed serous neuroendocrine neoplasm

混合性浆液性-神经内分泌肿瘤

                                         ii.    Glandular intraepithelial neoplasia腺上皮内瘤变

1.    Glandular intraepithelial neoplasia,Low-grade

腺上皮内瘤变,低级别

2.    Glandular intraepithelial neoplasia,High-grade

腺上皮内瘤变,高级别

                                        iii.    Intraductal papillary mucinous neoplasm导管内乳头状黏液性肿瘤

1.    Intraductal papillary mucinous neoplasm,Low-grade

导管内乳头状黏液性肿瘤,低级别

2.    Intraductal papillary mucinous neoplasm,High-grade

导管内乳头状黏液性肿瘤,高级别

3.    Associated with invasive adenocarcinoma

伴有浸润性腺癌

                                       iv.    Intraductal oncocytic papillary neoplasm导管内嗜酸性乳头状肿瘤

1.    Intraductal oncocytic papillary neoplasm,Low-grade

导管内嗜酸性乳头状肿瘤,低级别

2.    Intraductal oncocytic papillary neoplasm,High-grade

导管内嗜酸性乳头状肿瘤,高级别

3.    Associated with invasive adenocarcinoma

伴有浸润性腺癌

                                        v.    Intraductal tubulopapillary neoplasm

导管内管状乳头状肿瘤

                                       vi.    Mucinous cystic neoplasm黏液性囊性肿瘤

1.    Mucinous cystic neoplasm,Low-grade

黏液性囊性肿瘤,低级别

2.    Mucinous cystic neoplasm,High-grade

黏液性囊性肿瘤,高级别

3.    Associated with invasive adenocarcinoma

伴有浸润性腺癌

b.    Malignant epithelial tumors恶性上皮性肿瘤

                                          i.    Ductal adenocarcinoma导管腺癌

1.    Colloid carcinoma

胶样癌

2.    Poorly cohesive carcinoma

低黏附性癌

3.    Signet ring cell carcinoma

印戒细胞癌

4.    Medullary carcinoma

髓样癌

5.    Adenosquamous carcinoma

腺鳞癌

6.    Hepatoid carcinoma

肝样癌

7.    Large cell carcinoma with rhabdoid phenotype

具有横纹肌样表型的大细胞癌

8.    Carcinoma, undifferentiated

未分化癌

                                         ii.    Acinar cell carcinoma腺泡细胞癌

1.    Acinar cell cystadenocarcinoma

腺泡细胞囊腺癌

2.    Mixed acinar neuroendocrine carcinoma

混合性腺泡-神经内分泌癌

3.    Mixed acinar neuroendocrine ductal adenocarcinoma

混合性腺泡-神经内泌-导管腺癌

4.    Mixed acinar and ductal adenocarcinoma

混合性腺泡-导管腺癌

                                        iii.    Pancreatoblastoma

胰母细胞瘤

                                       iv.    Solid pseudopapillary neoplasm of pancreas

胰腺实性-假乳头状肿瘤

c.    Pancreatic neuroendocrine neoplasms胰腺神经内分泌肿瘤

                                          i.    Pancreatic neuroendocrine microadenoma

胰腺神经内分泌微腺瘤

                                         ii.    Neuroendocrine tumor神经内分泌肿瘤

1.    Neuroendocrine tumor, grade 1

胰腺神经内分泌肿瘤,G1

2.    Neuroendocrine tumor, grade 2

胰腺神经内分泌肿瘤,G2

3.    Neuroendocrine tumor, grade 3

胰腺神经内分泌肿瘤,G3

                                        iii.    Pancreatic neuroendocrine tumor, nonfunctioning非功能型胰腺神经内分泌肿瘤

1.    Oncocytic

嗜酸细胞型

2.    Pleomorphic

多形性

3.    Clear cell

透明细胞型

4.    Cystic

囊性型                                                                                                                               

                                       iv.    Functioning pancreatic neuroendocrine tumor 功能型胰腺神经内分泌肿瘤

1.    Insulinoma

胰岛素瘤

2.    Gastrinoma

胃泌素瘤

3.    VIPoma

血管活性肠肽瘤

4.    Glucagonoma

胰高血糖素瘤

5.    Somatostatinoma

生长抑素瘤

6.    ACTH-producing tumor

促肾上腺皮质激素生成性肿瘤

7.    Enterochromaffin cell carcinoid

肠嗜铬细胞瘤类癌

8.    Serotonin producing tumor

5-羟色胺生成性肿瘤

                                        v.    Neuroendocrine carcinoma神经内分泌癌

1.    Large cell neuroendocrine carcinoma

大细胞神经内分泌癌

2.    Small cell neuroendocrine carcinoma

小细胞神经内分泌癌

                                       vi.    Mixed neuroendocrine–non-–neuroendocrine neoplasm (MiNEN)混合性神经-非神经内分泌肿瘤

1.    Mixed acinar–endocrine carcinoma

混合性腺泡细胞-内分泌癌

2.    Mixed acinar–neuroendocrine carcinoma

混合性腺泡细胞-神经内分泌癌

3.    Mixed acinar–endocrine–ductal carcinoma

混合性腺泡细胞-神经内分泌-导管癌


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